Skip to main content
Active

110 E Greenville Street

Anderson, SC 29621

Active 46 days on market Listing ID GVL 1594425

$2,300,000

Est. $13,221/mo See my rate

— Beds
— Baths
— Sq Ft
— Built
1.21 acres Retail Listed Jun 11, 2026 Updated Jun 11, 2026 HOA None

Prime multi-building corner commercial investment opportunity

Investment Potential

Endless investment potential on one of Anderson's most iconic corners! Nestled in one of Anderson’s most prominent and well-trafficked locations, this multi-building, multi-tenant portfolio property offers an unparalleled opportunity for business owners and investors alike.

Iconic Block Location

Occupying nearly half of one of the city’s most iconic blocks, this property is a cornerstone of Anderson’s bustling commercial hub. Its strategic location at the intersection of E Greenville Street and Main Street ensures maximum visibility and accessibility, making it an ideal destination for retail, professional services, or dining establishments.

Acreage And Space

Spanning 1.21 acres with over 14,000 square feet of versatile space, the property features multiple buildings designed to accommodate a range of commercial needs.

Corner Frontage Access

Positioned at the corner of E Calhoun and McDuffie Streets, the site also enjoys frontage along E Greenville Street, with red-light access on three sides to ensure seamless traffic flow for patrons and clients.

Flexible Tenant Layout

The property’s layout offers flexibility, allowing tenants to customize the spaces to suit their specific requirements, whether they are a retail vendor, restaurateur, or professional office provider.

Visibility And Traffic

The visibility and accessibility of this property are unmatched. Its location within the heart of Anderson places it amidst thriving businesses, providing a steady stream of potential customers. The property’s position on key city streets ensures consistent exposure to both pedestrian and vehicle traffic, making it a highly desirable site for a range of ventures.

Vibrant Economic Setting

Whether you’re looking to establish a flagship retail store, expand a professional office portfolio, or create a dining destination in one of South Carolina’s fastest-growing cities, this property offers the space, location, and flexibility needed to bring your vision to life. With its prime location and multi-tenant potential, this commercial listing is a rare opportunity to secure a presence in the heart of Anderson’s vibrant economic landscape. Don’t miss your chance to be part of this thriving community.

Property Details

Property Overview

County
Anderson

Interior Details

Flooring
  • Carpet
  • Concrete Slab/Grade
  • Linoleum

Exterior Features

Roof
  • Other
Construction
  • Block
  • Brick

Lot And Land

Lot Size Acres
1.21

Utilities And Systems

Sewer
  • Public Sewer
Cooling
  • Electric
Heating
  • Natural Gas
Water Source
  • Public

Tax Information

Annual Tax
17722

Listed by Sherry L Traynum of Howard Hanna Allen Tate/Pine to Palm Realty

Location

Address
110 E Greenville Street
City
Anderson, SC 29621
County
Anderson
Get directions: Apple MapsGoogle Maps
Explore the area →

The information is being provided by Greater Greenville MLS. Information deemed reliable but not guaranteed. Information is provided for consumers’ personal, non-commercial use, and may not be used for any purpose other than the identification of potential properties for purchase. Copyright 2026 Greater Greenville MLS. All Rights Reserved.

Schedule a Tour

110 E Greenville Street, Anderson, SC, 29621

Step 1 of 2

Note: All times are Eastern Time (ET). Tours must be scheduled at least 2 hours in advance.

Time

Add a place